| 2025-07-27 14:00:4227. Juli 2025 |   Chemie Leipzig — 1. FC Magdeburg II | 14:00:4214:00 | - | Alfred-Kunze-Sportpark | 1 |
- |
| 2025-08-03 14:00:013. August 2025 |  Greifswalder FC — Chemie Leipzig | 14:00:0114:00 | - | Volksstadion Greifswald | 2 |
- |
| 2025-08-10 14:00:1610. August 2025 |  Chemnitzer FC — Chemie Leipzig | 14:00:1614:00 | - | Stadion an der Gellertstraße | 3 |
- |
| 2025-08-24 14:00:3524. August 2025 |  Chemie Leipzig — Babelsberg 03 | 14:00:3514:00 | - | Alfred-Kunze-Sportpark | 4 |
- |
| 2025-08-27 14:00:1027. August 2025 |  BFC Preussen — Chemie Leipzig | 14:00:1014:00 | - | | 5 |
- |
| 2025-08-31 14:00:1131. August 2025 |  Chemie Leipzig — Carl Zeiss Jena | 14:00:1114:00 | - | Alfred-Kunze-Sportpark | 6 |
- |
| 2025-09-14 14:00:1714. September 2025 |  Hallescher Fußballclub e.V. — Chemie Leipzig | 14:00:1714:00 | - | LEUNA-CHEMIE-STADION | 7 |
- |
| 2025-09-17 14:00:0417. September 2025 |  Chemie Leipzig — Rot-Weiß Erfurt | 14:00:0414:00 | - | Alfred-Kunze-Sportpark | 8 |
- |
| 2025-09-21 14:00:2521. September 2025 |  Chemie Leipzig — BFC Dynamo | 14:00:2514:00 | - | Alfred-Kunze-Sportpark | 9 |
- |
| 2025-09-28 14:00:2428. September 2025 |  FSV Luckenwalde — Chemie Leipzig | 14:00:2414:00 | - | Werner-Seelenbinder-Stadion | 10 |
- |
| 2025-10-05 14:00:375. Oktober 2025 |  Chemie Leipzig — VSG Altglienicke | 14:00:3714:00 | - | Alfred-Kunze-Sportpark | 11 |
- |
| 2025-10-19 14:00:5019. Oktober 2025 |  Lokomotive Leipzig — Chemie Leipzig | 14:00:5014:00 | - | Bruno-Plache-Stadion | 12 |
- |
| 2025-10-26 14:00:5426. Oktober 2025 |  Chemie Leipzig — Hertha BSC U23 | 14:00:5414:00 | - | Alfred-Kunze-Sportpark | 13 |
- |
| 2025-11-02 14:00:482. November 2025 |  F.C. Hertha 03 Zehlendorf Berlin — Chemie Leipzig | 14:00:4814:00 | - | Ernst-Reuter-Sportfeld | 14 |
- |
| 2025-11-09 14:00:239. November 2025 |  Chemie Leipzig — ZFC Meuselwitz | 14:00:2314:00 | - | Alfred-Kunze-Sportpark | 15 |
- |
| 2025-11-23 14:00:4623. November 2025 |  FC Eilenburg — Chemie Leipzig | 14:00:4614:00 | - | Ilburg-Stadion | 16 |
- |
| 2025-11-30 14:00:4830. November 2025 |  Chemie Leipzig — FSV Zwickau | 14:00:4814:00 | - | Alfred-Kunze-Sportpark | 17 |
- |
| 2025-12-07 14:00:067. Dezember 2025 | 1. FC Magdeburg II — Chemie Leipzig | 14:00:0614:00 | - | | 18 |
- |
| 2025-12-14 14:00:0514. Dezember 2025 | Chemie Leipzig — Greifswalder FC | 14:00:0514:00 | - | Alfred-Kunze-Sportpark | 19 |
- |
| 2026-02-01 14:00:061. Februar 2026 | Chemie Leipzig — Chemnitzer FC | 14:00:0614:00 | - | Alfred-Kunze-Sportpark | 20 |
- |
| 2026-02-08 14:00:208. Februar 2026 | Babelsberg 03 — Chemie Leipzig | 14:00:2014:00 | - | Karl-Liebknecht-Stadion | 21 |
- |
