| 2021-07-25 14:05:5825. Juli 2021 |   FC Eilenburg - Chemie Leipzig | 14:05:5814:05 | - | Ilburg-Stadion | 1 |
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| 2021-07-28 19:00:2328. Juli 2021 |  Chemie Leipzig - Germania Halberstadt | 19:00:2319:00 | - | Alfred-Kunze-Sportpark | 2 |
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| 2021-08-01 14:05:021. August 2021 |  ZFC Meuselwitz - Chemie Leipzig | 14:05:0214:05 | - | bluechip-Arena | 3 |
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| 2021-08-07 16:00:017. August 2021 |  Chemie leipzig - Tasmania Berlin | 16:00:0116:00 | - | Alfred-Kunze-Sportpark | 4 |
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| 2021-08-13 19:00:3513. August 2021 |  Babelsberg 03 — Chemie Leipzig | 19:00:3519:00 | - | Karl-Liebknecht-Stadion | 5 |
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| 2021-08-17 19:00:5217. August 2021 |  Chemie Leipzig — Lichtenberg 47 | 19:00:5219:00 | - | Alfred-Kunze-Sportpark | 6 |
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| 2021-08-22 13:00:1222. August 2021 |  Hertha BSC U23 — Chemie Leipzig | 13:00:1213:00 | - | Karl-Liebknecht-Stadion | 7 |
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| 2021-08-28 13:00:0228. August 2021 |  Chemie Leipzig — Chemnitzer FC | 13:00:0213:00 | - | Alfred-Kunze-Sportpark | 8 |
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| 2021-08-31 19:00:0331. August 2021 |  Chemie Leipzig — FSV Luckenwalde | 19:00:0319:00 | - | Alfred-Kunze-Sportpark | 9 |
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| 2021-09-12 13:00:4412. September 2021 |  BFC Dynamo — Chemie Leipzig | 13:00:4413:00 | - | Friedrich-Ludwig-Jahn-Sportpark | 10 |
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| 2021-09-18 13:00:1218. September 2021 |  Chemie Leipzig — Optik Rathenow | 13:00:1213:00 | - | Alfred-Kunze-Sportpark | 11 |
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| 2021-09-25 13:00:0025. September 2021 |  Carl Zeiss Jena — Chemie Leipzig | 13:00:0013:00 | - | Ernst-Abbe-Sportfeld | 12 |
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| 2021-10-03 13:30:593. Oktober 2021 |  Chemie Leipzig — VfB Auerbach | 13:30:5913:30 | - | Alfred-Kunze-Sportpark | 13 |
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| 2021-10-17 13:30:4917. Oktober 2021 |  TeBe Berlin — Chemie Leipzig | 13:30:4913:30 | - | Mommsenstadion | 14 |
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| 2021-10-24 13:30:4724. Oktober 2021 |  Chemie Leipzig — Union Fürstenwalde | 13:30:4713:30 | - | Alfred-Kunze-Sportpark | 15 |
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| 2021-10-31 13:30:0231. Oktober 2021 |  Berliner AK — Chemie Leipzig | 13:30:0213:30 | - | Poststadion | 16 |
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| 2021-11-07 13:30:587. November 2021 |  Chemie Leipzig — VSG Altglienicke | 13:30:5813:30 | - | Alfred-Kunze-Sportpark | 17 |
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| 2021-11-21 13:30:0321. November 2021 |  Lokomotive Leipzig — Chemie Leipzig | 13:30:0313:30 | - | Bruno-Plache-Stadion | 18 |
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| 2021-11-28 13:30:2128. November 2021 |  Chemie Leipzig — Energie Cottbus | 13:30:2113:30 | - | Alfred-Kunze-Sportpark | 19 |
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| 2021-12-05 13:30:065. Dezember 2021 | Chemie Leipzig — FC Eilenburg | 13:30:0613:30 | - | Alfred-Kunze-Sportpark | 20 |
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| 2021-12-12 13:30:3412. Dezember 2021 | Germania Halberstadt — Chemie Leipzig | 13:30:3413:30 | - | Friedenstadion | 21 |
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| 2021-12-19 13:30:2219. Dezember 2021 | Chemie Leipzig — ZFC Meuselwitz | 13:30:2213:30 | - | Alfred-Kunze-Sportpark | 22 |
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| 2022-01-30 13:30:4330. Januar 2022 | Tasmania Berlin — Chemie Leipzig | 13:30:4313:30 | - | Werner-Seelenbinder-Sportpark | 23 |
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| 2022-02-06 13:30:396. Februar 2022 | Chemie Leipzig — Babelsberg 03 | 13:30:3913:30 | - | Alfred-Kunze-Sportpark | 24 |
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| 2022-02-13 13:30:5613. Februar 2022 | Lichtenberg 47 — Chemie Leipzig | 13:30:5613:30 | - | HOWOGE-Arena | 25 |
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| 2022-02-20 13:30:4920. Februar 2022 | Chemie Leipzig — Hertha BSC U23 | 13:30:4913:30 | - | Alfred-Kunze-Sportpark | 26 |
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| 2022-02-27 13:30:4027. Februar 2022 | Chemnitzer FC — Chemie Leipzig | 13:30:4013:30 | - | Stadion an der Gellertstraße | 27 |
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| 2022-03-06 13:30:496. März 2022 | FSV Luckenwalde — Chemie Leipzig | 13:30:4913:30 | - | Werner-Seelenbinder-Stadion | 28 |
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| 2022-03-13 13:30:4613. März 2022 | Chemie Leipzig — BFC Dynamo | 13:30:4613:30 | - | Alfred-Kunze-Sportpark | 29 |
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| 2022-03-20 13:30:3520. März 2022 | Optik Rathenow — Chemie Leipzig | 13:30:3513:30 | - | Stadion Rathenow | 30 |
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| 2022-04-03 13:30:303. April 2022 | Chemie Leipzig — Carl Zeiss Jena | 13:30:3013:30 | - | Alfred-Kunze-Sportpark | 31 |
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| 2022-04-06 19:00:456. April 2022 | VfB Auerbach — Chemie Leipzig | 19:00:4519:00 | - | Stadion Auerbach | 32 |
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| 2022-04-10 13:30:4010. April 2022 | Chemie Leipzig — TeBe Berlin | 13:30:4013:30 | - | Alfred-Kunze-Sportpark | 33 |
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| 2022-04-17 13:30:2817. April 2022 | Union Fürstenwalde — Chemie Leipzig | 13:30:2813:30 | - | Friesenstadion | 34 |
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| 2022-04-24 13:30:2024. April 2022 | Chemie Leipzig — Berliner AK | 13:30:2013:30 | - | Alfred-Kunze-Sportpark | 35 |
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| 2022-05-01 13:30:121. Mai 2022 | VSG Altglienicke — Chemie Leipzig | 13:30:1213:30 | - | Friedrich-Ludwig-Jahn-Sportpark | 36 |
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| 2022-05-08 13:30:088. Mai 2022 | Chemie Leipzig — Lokomotive Leipzig | 13:30:0813:30 | - | Alfred-Kunze-Sportpark | 37 |
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| 2022-05-15 13:30:5615. Mai 2022 | Energie Cottbus — Chemie Leipzig | 13:30:5613:30 | - | Stadion der Freundschaft | 38 |
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