| 2022-08-07 13:00:527. August 2022 |   Babelsberg 03 — Chemie Leipzig | 13:00:5213:00 | 4 - 2 | Karl-Liebknecht-Stadion | 1 |
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| 2022-08-13 13:00:2013. August 2022 |  Chemie Leipzig — VSG Altglienicke | 13:00:2013:00 | - | Alfred-Kunze-Sportpark | 2 |
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| 2022-08-19 19:00:5119. August 2022 |  FSV Luckenwalde — Chemie Leipzig | 19:00:5119:00 | - | Werner-Seelenbinder-Stadion | 3 |
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| 2022-08-28 13:00:3928. August 2022 |  Chemie Leipzig — Lichtenberg 47 | 13:00:3913:00 | - | Alfred-Kunze-Sportpark | 4 |
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| 2022-09-11 13:30:4311. September 2022 |  ZFC Meuselwitz — Chemie Leipzig | 13:30:4313:30 | - | bluechip-Arena | 5 |
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| 2022-09-17 13:00:5217. September 2022 |  Chemie Leipzig — Berliner AK | 13:00:5213:00 | - | Alfred-Kunze-Sportpark | 6 |
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| 2022-10-02 13:00:522. Oktober 2022 |  Chemnitzer FC — Chemie Leipzig | 13:00:5213:00 | - | Stadion an der Gellertstraße | 7 |
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| 2022-10-09 13:00:109. Oktober 2022 |  Chemie Leipzig — Carl Zeiss Jena | 13:00:1013:00 | - | Alfred-Kunze-Sportpark | 8 |
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| 2022-10-16 13:00:0816. Oktober 2022 |  Lokomotive Leipzig — Chemie Leipzig | 13:00:0813:00 | - | Bruno-Plache-Stadion | 9 |
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| 2022-10-23 13:00:5623. Oktober 2022 |  Chemie Leipzig — Hertha BSC U23 | 13:00:5613:00 | - | Alfred-Kunze-Sportpark | 10 |
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| 2022-10-30 13:00:0130. Oktober 2022 |  Viktoria Berlin — Chemie Leipzig | 13:00:0113:00 | - | Stadion Lichterfelde | 11 |
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| 2022-11-06 13:00:016. November 2022 |  Chemie Leipzig — TeBe Berlin | 13:00:0113:00 | - | Alfred-Kunze-Sportpark | 12 |
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| 2022-11-13 13:00:1213. November 2022 |  Greifswalder FC — Chemie Leipzig | 13:00:1213:00 | - | Volksstadion Greifswald | 13 |
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| 2022-11-27 13:00:2427. November 2022 |  Chemie Leipzig — BFC Dynamo | 13:00:2413:00 | - | Alfred-Kunze-Sportpark | 14 |
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| 2022-12-04 13:00:074. Dezember 2022 |  Germania Halberstadt — Chemie Leipzig | 13:00:0713:00 | - | Friedenstadion | 15 |
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| 2022-12-11 13:00:0611. Dezember 2022 |  Chemie Leipzig — Rot-Weiß Erfurt | 13:00:0613:00 | - | Alfred-Kunze-Sportpark | 16 |
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| 2022-12-18 13:00:2418. Dezember 2022 |  Energie Cottbus — Chemie Leipzig | 13:00:2413:00 | - | Stadion der Freundschaft | 17 |
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| 2023-01-29 13:00:2529. Januar 2023 | Chemie Leipzig — Babelsberg 03 | 13:00:2513:00 | - | Alfred-Kunze-Sportpark | 18 |
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| 2023-02-05 13:00:295. Februar 2023 | VSG Altglienicke — Chemie Leipzig | 13:00:2913:00 | - | Friedrich-Ludwig-Jahn-Sportpark | 19 |
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| 2023-02-12 13:00:3012. Februar 2023 | Chemie Leipzig — FSV Luckenwalde | 13:00:3013:00 | - | Alfred-Kunze-Sportpark | 20 |
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| 2023-02-19 13:00:1819. Februar 2023 | Lichtenberg 47 — Chemie Leipzig | 13:00:1813:00 | - | HOWOGE-Arena | 21 |
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| 2023-02-26 13:00:0326. Februar 2023 | Chemie Leipzig — ZFC Meuselwitz | 13:00:0313:00 | - | Alfred-Kunze-Sportpark | 22 |
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| 2023-03-05 13:00:545. März 2023 | Berliner AK — Chemie Leipzig | 13:00:5413:00 | - | Poststadion | 23 |
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| 2023-03-12 13:00:3912. März 2023 | Chemie Leipzig — Chemnitzer FC | 13:00:3913:00 | - | Alfred-Kunze-Sportpark | 24 |
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| 2023-03-19 13:00:5719. März 2023 | Carl Zeiss Jena — Chemie Leipzig | 13:00:5713:00 | - | Ernst-Abbe-Sportfeld | 25 |
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| 2023-04-02 13:00:472. April 2023 | Chemie Leipzig — Lokomotive Leipzig | 13:00:4713:00 | - | Alfred-Kunze-Sportpark | 26 |
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| 2023-04-09 13:00:349. April 2023 | Hertha BSC U23 — Chemie Leipzig | 13:00:3413:00 | - | Olympiapark Berlin | 27 |
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| 2023-04-16 13:00:2416. April 2023 | Chemie Leipzig — Viktoria Berlin | 13:00:2413:00 | - | Alfred-Kunze-Sportpark | 28 |
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| 2023-04-23 13:00:4723. April 2023 | TeBe Berlin — Chemie Leipzig | 13:00:4713:00 | - | Mommsenstadion | 29 |
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| 2023-04-30 13:00:3430. April 2023 | Chemie Leipzig — Greifswalder FC | 13:00:3413:00 | - | Alfred-Kunze-Sportpark | 30 |
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| 2023-05-07 13:00:257. Mai 2023 | BFC Dynamo — Chemie Leipzig | 13:00:2513:00 | - | Friedrich-Ludwig-Jahn-Sportpark | 31 |
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| 2023-05-14 13:00:1414. Mai 2023 | Chemie Leipzig — Germania Halberstadt | 13:00:1413:00 | - | Alfred-Kunze-Sportpark | 32 |
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| 2023-05-21 13:00:5221. Mai 2023 | Rot-Weiß Erfurt — Chemie Leipzig | 13:00:5213:00 | - | Steigerwaldstadion | 33 |
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| 2023-05-28 13:00:3328. Mai 2023 | Chemie Leipzig — Energie Cottbus | 13:00:3313:00 | - | Alfred-Kunze-Sportpark | 34 |
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